Hyper-ERAS Program for Highly Selective Colorectal Cancer Patients

P

Peking University Cancer Hospital & Institute

Status

Enrolling

Conditions

ERAS
Colorectal Cancer

Treatments

Procedure: Hyper-ERAS Program

Study type

Interventional

Funder types

Other

Identifiers

NCT06256315
PKUCH Hyper-ERAS research

Details and patient eligibility

About

This clinical trial aims to explore the safety and effectiveness of the Hyper-ERAS rehabilitation protocol for colorectal cancer patients and the feasibility of discharge within 48 hours.

Full description

The Hype-ERAS protocol includes preoperative education, intraoperative quality control, postoperative preventive analgesia, early ambulation, early recovery of diet, early removal of drainage tube, urinary catheter, and gastric tube, discharge within 48 hours after surgery, and standardized follow-up outside the hospital. Patients treated with the Hyper-ERAS rehabilitation protocol and discharged within 48 hours were in group A. Patients who were treated with Hyper-ERAS protocol and had a postoperative hospital stay of more than 48 hours were classified as group B. Patients eligible but not treated with the Hyper-ERAS rehabilitation protocol during the same period were in group C (Control group). The postoperative recovery of each group was compared to explore the safety and efficacy of Hyper-ERAS rehabilitation program in patients with colorectal cancer.

Enrollment

160 estimated patients

Sex

All

Ages

18 to 79 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Pathologically confirmed colorectal cancer.
  2. The position of the anastomosis is above the peritoneal reflection.
  3. Age range from 18 to 79 years old.
  4. No surgical contraindications.
  5. The patient has good compliance and can understand the concept of rapid recovery.
  6. Possess basic nursing conditions outside the hospital, and can arrive at the hospital within 30 minutes after discharge.

Exclusion criteria

  • The exclusion criteria consisted of three parts: the first exclusion at enrollment, the second exclusion after surgery, and the third exclusion before discharge, corresponding to three exclusion criteria. 1st: Exclusion criteria at enrollment: 1). ASA grade ≥ grad 4. 2). Having previous surgical history, complex surgery, or combined/multiple organ resection with large trauma. 3). patients with complete obstruction or obvious intestinal edema and dilatation. 4). application of high-dose hormones, immunosuppressants, and preoperative radiotherapy. 5). Emergency surgery. 6). Patients with self-care difficulties for physical or mental reasons. 7). Pregnant patients. 8). to accept other studies simultaneously. 9). Inability to understand or accept the concept of enhanced recovery after surgery; 2nd: Postoperative exclusion criteria: 1). Adverse events occurred during preoperative preparation, such as perforation, massive bleeding, obstruction, fever, etc. 2). Adverse events occurred during the operation, such as intraoperative massive bleeding (≥400ml), unsatisfactory anastomosis, intraoperative perforation, unstable vital signs, etc. 3). Have any other conditions deemed ineligible for enrollment; 3rd: Exclusion criteria before discharge: 1). Body temperature above 37.5℃. 2) The food intake cannot meet the basic physiological needs, such as liquid food < 1000ml/ day. 3) with obvious abdominal distension, vomiting, cough and expectoration, dizziness, chest tightness, and other discomfort. 4) patients with abnormal laboratory indicators and abnormal nature of drainage fluid requiring hospitalization, such as bleeding, infection, leakage, etc. 5). Poor recovery of field activities and inability to care for themselves. 6). Have any other conditions deemed unsuitable for discharge. 7). Refusal to discharge.

Trial design

Primary purpose

Supportive Care

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

160 participants in 3 patient groups

Group A:Hyper-ERAS(Length of Postoperative Hospital Stay<48h)
Experimental group
Description:
Patients treated with the Hyper-ERAS rehabilitation protocol and discharged within 48 hours were in group A.
Treatment:
Procedure: Hyper-ERAS Program
Group B:Hyper-ERAS(LOPS>48h)
Experimental group
Description:
Patients treated with the ERAS rehabilitation protocol and discharged in more than 48 hours were in group B.
Treatment:
Procedure: Hyper-ERAS Program
Group C:Control group
No Intervention group
Description:
Patients eligible but not treated with the Hyper-ERAS rehabilitation protocol during the same period were in group C.

Trial contacts and locations

1

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Central trial contact

Changlong Li; Lin Wang, M.D.

Data sourced from clinicaltrials.gov

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