Hyperalgesia and NMDA Receptor Antagonist

Seoul National University

Status: Unknown

Conditions: Pain

Treatments: Drug: ketamine; Drug: Magnesium Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT02087202

hyperalgesia

Details and patient eligibility

About

NMDA receptor is administered and postoperative remote hyperalgesia is investigated.

Full description

NMDA receptor is adminstered and postoperative tertiary hyperalgesia is investigated.

QST and pain measures for remote hyperalgesia are compared between control and magnesium or ketamine group.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA1-2

Exclusion criteria

• contraindication to the study drugs

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups, including a placebo group

magnesium

Experimental group

Description:

magnesium is added perioperatively to those patients undergoing staged total knee arthroplasty and other surgeries.

Treatment:

Drug: Magnesium Sulfate

ketamine

Experimental group

Description:

ketamine is administered to those patients undergoing stated TKA and other operations.

Treatment:

Drug: ketamine

control

Placebo Comparator group

Description:

normal saline (placebo) is administered to the patients.