Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance (HOTAIR)

University of Adelaide

Status: Completed

Conditions: Obesity; Type 2 Diabetes

Treatments: Procedure: Hyperbaric Oxygen Treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01361971

RAH100615

Details and patient eligibility

About

Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.

Enrollment: 20 patients

Sex: Male

Ages: 45 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Obese men with and without type 2 diabetes aged 45-70
• Lean men without type 2 diabetes aged 45-70

Exclusion criteria

• smokers
• claustrophobic
• sleep apnoea
• blood donor
• exercise more than 2 times per week
• under certain medications eg: bleomycin,corticosteroid