Hyperbaric VO2max Study

Duke University

Status and phase: Terminated; Phase 2

Conditions: Exercise Training

Treatments: Drug: Oxygen; Procedure: Hyperoxic hyperbaric interval exercise training; Procedure: Normoxic, normobaric, interval exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT02356900

Pro00060147

Details and patient eligibility

About

This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude. Subjects will complete a short, high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after this training phase, all subjects will be tested for maximum aerobic capacity at a simulated high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of mitochondrial oxidative capacity in a skeletal muscle biopsy.

A group of individuals of similar characteristics completing this training program in a normoxic-normobaric environment will serve as a control.

Enrollment: 25 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy, recreationally active or sedentary individuals

Exclusion criteria

• VO2max < 35 ml/kg/min - male 30 ml/kg/min - female
• chronic cardiovascular or pulmonary diseases
• history of pneumothorax
• active smoker
• pregnant women
• non-english speaking
• not in full mental capacity
• blind
• sickle cell trait or disease

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

Hyperoxic, Hyperbaric

Experimental group

Description:

Hyperoxic hyperbaric interval exercise training Six sessions of 30 min.of High-intensity interval training completed on a 3-times a week basis at 1.4 ATA of oxygen in a hyperbaric chamber.

Treatment:

Drug: Oxygen

Procedure: Hyperoxic hyperbaric interval exercise training

Normoxic, Normobaric

Sham Comparator group

Description:

Normoxic, normobaric, interval exercise training Six sessions of 30 min.of High-intensity interval training completed on a 3-times a week basis.

Treatment:

Procedure: Normoxic, normobaric, interval exercise training