Hypercapnia: Cognitive Effects and Monitoring

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Duke University

Status

Completed

Conditions

Hypercapnia
Nitrogen Narcosis
Immersion
Diving
Exercise

Treatments

Other: NO exercise at depth
Other: exercise at depth

Study type

Interventional

Funder types

Other

Identifiers

NCT01782625
SPS 181258 (Registry Identifier)
Pro00036937

Details and patient eligibility

About

The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses: 1. An algorithm can be developed which predicts cognitive performance in immersed exercising divers, based on the exhaled carbon dioxide (PETCO2) and the diver's inspired partial pressures of oxygen and nitrogen (PIO2 and PIN2). 2. PETCO2 using mass spectrometry is an accurate estimate of arterial carbon dioxide (PaCO2) at rest and during immersed exercise and can be used as a PaCO2 surrogate at levels exceeding 50 mmHg and depths up to 158 fsw (gas density 6.4 g/l, similar to 165 fsw density of 6.8 g/l).

Enrollment

58 patients

Sex

Male

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy,
  • male,
  • age greater than 18,
  • age less than 50

Exclusion criteria

  • smoker,
  • asthma,
  • cardiac disease,
  • inability to pedal a bicycle ergometer,
  • inability to perform vigorous exercise

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

58 participants in 4 patient groups

dive to 122 feet, no exercise
Experimental group
Description:
Subjects will undergo a simulated dive to a maximum depth of 122 feet of seawater with no exercise at depth
Treatment:
Other: NO exercise at depth
dive to 158 feet, no exercise
Experimental group
Description:
Subjects will undergo a simulated dive to a maximum depth of 154 feet of seawater with no exercise at depth
Treatment:
Other: NO exercise at depth
dive to 122 feet, exercise
Experimental group
Description:
Subjects will undergo a simulated dive to a maximum depth of 122 feet of seawater with exercise at depth
Treatment:
Other: exercise at depth
dive to 158 feet, exercise
Experimental group
Description:
Subjects will undergo a simulated dive to a maximum depth of 154 feet of seawater with exercise at depth.
Treatment:
Other: exercise at depth

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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