Hypercortisolism and Epicardial Adipose Tissue (Hyper-Cor)

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Completed

Conditions

Hypercortisolism

Treatments

Device: MRI at 3 Tesla

Biological: Blood samples for measuring adiponectin, leptin and omentin plasma

Study type

Interventional

Funder types

Other

Identifiers

NCT02335996

2014-A01302-45 (Registry Identifier)

2014-23

RCAPHM14_0343 (Other Identifier)

Details and patient eligibility

About

Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed. Hypercortisolic patients represent an ideal in vivo model to determine the interactions between glucocorticoids and ectopic fat development.

Enrollment

43 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Major, male or female
Introducing an active or healed hypercortisolism caused by Cushing's disease
signed informed consent.

Exclusion criteria

Elderly patients under 18 years
Pregnant or lactating women
Previous history of myocardial infarction
Antecedent congenital cardiomyopathy
Adrenocorticotropic hormone-independent Hyperadrenocorticism
Hyperadrenocorticism by ectopic Adrenocorticotropic hormone secretion
Treatment with corticosteroids or insulin
Specific contraindication to the achievement of Nuclear Magnetic Resonance (metal heart valves, pacemakers, metallic foreign body, claustrophobia)
Persons deprived of liberty
Persons not affiliated to a social security scheme
People unable to give their consent in writing (in person or with the assistance of a third party).