Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock

Ain Shams University

Status: Completed

Conditions: Mortality; Intensive Care Unit; Left Ventricular Ejection Fraction; Hyperdynamic; Septic Shock

Treatments: Device: Transthoracic echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT06993948

MD 260/2022

Details and patient eligibility

About

The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.

Full description

Cardiovascular dysfunction is increasingly being recognized as a significant complication in sepsis, affecting patient outcomes.

Among the key parameters used to evaluate cardiac performance is the left ventricular ejection fraction (LVEF), typically assessed via transthoracic echocardiography (TTE).

LVEF has been extensively studied; most investigations into preserved ejection fraction tend to group all values ≥50% together, thereby overlooking the potential clinical implications of LVEF ≥70%, often referred to as hyperdynamic LVEF (HDLVEF).

Enrollment: 235 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18 years.
• Both sexes.
• Patients who were diagnosed with septic shock.

Exclusion criteria

• Patients with previously documented abnormal transthoracic echocardiography (TTE) findings, such as severe valvular disease, poor echocardiographic windows, patients admitted to cardiothoracic intensive care unit (ICU), and those not meeting sepsis criteria.

Trial design

235 participants in 1 patient group

Septic shock group

Description:

Patients underwent left ventricular ejection fraction (LVEF) assessment using two-dimensional echocardiography using visual estimation.

Treatment:

Device: Transthoracic echocardiography