Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury (BRAIN-GLULAC)

Rigshospitalet

Status: Completed

Conditions: Hyperlactatemia; Hyperglycemia; Acute Brain Injury

Treatments: Other: Sampling of blood and cerebrospinal fluid

Study type: Observational

Funder types: Other

Identifiers

NCT05505396

P-2022-321

Details and patient eligibility

About

This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome.

Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.

Enrollment: 459 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Admission to the neurointensive care unit at Rigshospitalet
• Diagnosis of acute brain injury categorised as TBI, SAH, ICH, ischaemic stroke, or other conditions

Exclusion criteria

• Brain death before inclusion
• Closest relatives do not understand written and spoken Danish or English