Hyperglycemia, Exercise, and Endothelial Function

University of Iowa

Status: Completed

Conditions: Endothelial Function; Hyperglycemia

Treatments: Dietary Supplement: GLU; Behavioral: GLU+EX

Study type: Interventional

Funder types: Other

Identifiers

NCT03651713

201807752

Details and patient eligibility

About

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Full description

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Enrollment: 32 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy young men 18-35 years of age.

Exclusion criteria

• Hypertension,
• Hyperlipidemia,
• Smoking,
• Heart disease,
• Chest pain upon exertion,
• Previous heart surgeries or history of arrhythmias,
• Diabetes,
• Obesity (body mass index ≥30kg/m2),
• Kidney disease,
• Pulmonary disease,
• Autonomic disorders,
• Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
• Current use of medications which influence outcome measures

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

GLU+EX

Experimental group

Description:

Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.

Treatment:

Behavioral: GLU+EX

GLU

Active Comparator group

Description:

Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.

Treatment:

Dietary Supplement: GLU