Hyperglycemia in Patients With Takotsubo Syndrome

University of Campania "Luigi Vanvitelli"

Status: Completed

Conditions: Takotsubo Cardiomyopathy

Treatments: Other: To report number of HF events and deaths

Study type: Observational

Funder types: Other

Identifiers

NCT04684004

02.12.20

Details and patient eligibility

About

Patients with Takotsubo cardiomiopathy (TTC) have over-inflammation and over-sympathetic tone. However, these conditions could cause higher rate of heart failure (HF) events and deaths at 2 years of follow-up. Conversely, hyperglycemia vs. normoglycemia could result in over expression of inflammatory markers and catecholamines thta could result in higher rate of HF and deaths at 2 years of follow-up in TTC patients.

Enrollment: 40 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute onset of a cardiovascular event, usually associated with substernal chest pain, initially regarded as STEMI/evolving coronary syndrome;
• cardiac biomarker modifications (creatine kinase-MB and troponin I);
• systolic dysfunction, predominantly characterized by akinesia/hypokinesia of the mid-to-distal portion of the left ventricle (LV) chamber, with hyper-contractile basal LV.

Exclusion criteria

• patients with previous previous myocardial infarction;
• patients with previous TTC event;
• patients affected by chronic kidney, liver, and cerebrovascular diseases.

Trial design

40 participants in 2 patient groups

TTC patients with hyperglycemia

Description:

These patients will be hospitalized for TTC acute event. These patients will be characterized by higher blood glucose values at admission, and so defined as hyperglycemics.

Treatment:

Other: To report number of HF events and deaths

TTC patients with normoglycemia

Description:

These patients will be hospitalized for TTC acute event. These patients will be characterized by normal blood glucose values at admission, and so defined as normoglycemics.

Treatment:

Other: To report number of HF events and deaths