Hyperinsulinemic Therapy in Sepsis

peter metrakos

Status

Unknown

Conditions

Sepsis

Treatments

Drug: Insulin

Study type

Interventional

Funder types

Other

Identifiers

NCT01244178

10-003-GEN

Details and patient eligibility

About

Insulin regulates blood sugar and acts to suppress inflammation. Hyperinsulinemic Therapy is a protocol for Insulin administration that involves the administration of a calculated higher dose of insulin into the blood stream. This therapy is called dextrose/insulin clamp. It has been shown to be safe and successful in maintaining normal glucose levels.

The objective of the study is to assess if the clamp can achieve a steady and normal blood glucose level in patients admitted to the intensive care unit with sepsis. Furthermore, if the higher insulin dose would lead to a drop in the inflammatory response seen in septic patients.

Enrollment

15 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Admission to the ICU with a diagnosis of Septic shock or Severe Sepsis.

Exclusion criteria

Age less than 18 years old.
Pregnancy.
Patients who cannot provide informed consent and there is no surrogate decision maker.
A delay of more than 24 hours between eligibility and randomization.
Patients admitted to the intensive care unit for treatment of diabetic ketoacidosis or hyperosmolar state.
Imminent death.
Patients who the treating clinicians are not committed to full supportive care. This is confirmed by a documented treatment-limitation order that exceeds a "do-not-resuscitation" order.