Hypermetabolism in ALS Using Six REE Formulas

University of Limoges (UL)

Status: Completed

Conditions: Amyotrophic Lateral Sclerosis

Treatments: Other: Assesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.

Study type: Observational

Funder types: Other

Identifiers

NCT03382392

mREE

Details and patient eligibility

About

Introduction: About 50-60% of Amyotrophic Lateral Sclerosis (ALS) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (REE) compared to theoretical values. Harris and Benedict's (HB) formula is the equation mainly used to predict REE, but others are also applied in current practice. The present study aimed to assess REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.

Nutritional assessments were performed in ALS patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). Weight, height and body composition (by bioimpedance analysis) were assessed.

EE was measured (mREE) by indirect calorimetry and calculated (cREE) using HB 1919 and 1984, World Schofield, De Lorenzo, Johnstone and Mifflin formulas. Mann-Whitney and Chi2 tests were used to compare the equations.

Enrollment: 449 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ALS patients
• 18 years old or more
• IC and nutritional assessment within 1.5 months
• delay between diagnosis and IC < 12 months

Exclusion criteria

Trial design

449 participants in 3 patient groups

ALS

Treatment:

Other: Assesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.

control 1

control 2