Hyperoxemia and Ventilator-associated Pneumonia (SOH-VAP)

University Hospital, Lille

Status: Completed

Conditions: Mechanical Ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT03434821

2016_73

2017-A01934-49 (Other Identifier)

Details and patient eligibility

About

The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence.

• SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia.
• Patients with VAP will be prospectively identified.
• Patient characteristics and risk factors for VAP will be prospectively collected.
• Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence.

Patients with VAP will be compared with those with no VAP

Enrollment: 534 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients admitted to the ICU
• Expected duration of mechanical ventilation > 48h
• Signed informed consent
• Social insurance

Exclusion criteria

• Pregnancy or breast feeding
• No informed consent
• Hyperbaric oxygen treatment
• Prisoners and patients under guardianship