Hyperoxemia and Ventilator-associated Pneumonia (SOH-VAP)

U

University Hospital, Lille

Status

Completed

Conditions

Mechanical Ventilation

Study type

Observational

Funder types

Other

Identifiers

NCT03434821
2016_73
2017-A01934-49 (Other Identifier)

Details and patient eligibility

About

The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence. SpO2 will be continuously recorded in order to determine the percentage of time spent with hyperoxemia. Patients with VAP will be prospectively identified. Patient characteristics and risk factors for VAP will be prospectively collected. Oxidant stress will be prospectively investigated in study patients: glutathion peroxidase (GPX), plasmatic superoxyde dismutase (SOD), total plasmatic antioxidant status (SAT) and urinary 8-isoprostanes will be performed at ICU admission, once a week, and at VAP occurrence. Patients with VAP will be compared with those with no VAP

Enrollment

534 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients admitted to the ICU
  • Expected duration of mechanical ventilation > 48h
  • Signed informed consent
  • Social insurance

Exclusion criteria

  • Pregnancy or breast feeding
  • No informed consent
  • Hyperbaric oxygen treatment
  • Prisoners and patients under guardianship

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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