Hyperoxic Oxidative Stress During Abdominal Surgery

Istanbul University

Status: Completed

Conditions: Response to Hyperoxia

Treatments: Other: Fraction of inspired oxygen 40%; Other: Fraction of inspired oxygen 80%

Study type: Interventional

Funder types: Other

Identifiers

NCT01793454

36048

Details and patient eligibility

About

Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

Enrollment: 40 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II

Exclusion criteria

• Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition.

Patients will be recruited through general surgery service of our hospital

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

40% oxygen

Active Comparator group

Description:

Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery.

Treatment:

Other: Fraction of inspired oxygen 40%

80% oxygen

Active Comparator group

Description:

Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery.

Treatment:

Other: Fraction of inspired oxygen 80%