Hypertension and Injury

Klinik für Kardiologie, Pneumologie und Angiologie

Status: Completed

Conditions: CAD; Arterial Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT02795377

12-011 (Other Identifier)

Hypertension and Injury

Details and patient eligibility

About

Membrane microparticles are submicron fragments of membrane vesicles shed from various cell types. Circulating endothelial microparticles have been proposed as markers of endothelial injury. However, which mechanical forces contribute to their release is not clear.

Full description

In a first series subjects (50% hypertensives) with and without arterial hypertension and no Coronary Artery Disease (CAD) (n=50) will be recruited. MP subpopulations will be discriminated by flow cytometry according to the expression of established surface antigens including CD31+/41-, CD144+, and CD62e+. Besides office and ambulatory 24h blood pressure measurements, pulse wave analysis will be performed to determine central blood pressure, augmentation index (AIX), and pulse wave velocity. Endothelial function (Flow-mediated dilation, FMD), arterial pulsatile stretch (fractional diameter changes, FDC), and wall-shear-stress (WSS) will be measured in the same segment of the brachial artery (BA) by ultrasound. In a second series, the investigators will take measurements in subjects with hypertensive crises (SBP>180 mmHg) (n=20) before and after 4h and normalization of arterial BP by urapidil. In a third series, the investigators will take measurement in subjects with stable CAD (n=10) before and after transfemoral coronary diagnostic angiography.

Enrollment: 80 patients

Sex: Male

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male subjects with or without arterial hypertension, hypertensive crises, stable CAD
• written informed consent

Exclusion criteria

• subjects with manifest peripheral artery, or cerebrovascular disease, acute inflammation (CRP>0.6 mg/dl), malignancies, arrhythmias

Trial design

80 participants in 4 patient groups

male subjects with arterial hypertension

Description:

Measurements will be taken at baseline.

male subjects without arterial hypertension and no CAD

Description:

Measurements will be taken at baseline.

male subjects with hypertensive crises

Description:

Measurements will be taken before and after 4 hours and normalization of arterial blood pressure by urapidil.

male subjects with stable CAD

Description:

Measurements will be taken before and after transfemoral coronary diagnostic angiography.