Hypertension, Ethnicity and Exercise Trial (HYPE2X)

Catholic University (KU) of Leuven

Status: Completed

Conditions: Hypertension

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06824805

183/2020

Details and patient eligibility

About

The main aim of this study is to investigate the acute effects of a single bout of isometric handgrip exercise (IHG) and a single bout of aerobic endurance exercise (AEX) on blood pressure, both immediately after exercise and during the subsequent activities of daily living in patients with high-normal to grade 1 hypertension of South-Asian or African descent living in Suriname.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Age 18 - 65 years

  • Patients with high- normal BP (SBP: 130 - 139 mmHg or and DBP: 85 - 89 mmHg) or stage I hypertension (SBP: 140 - 159 mmHg or DBP: 90 - 99 mmHg) according to the ESC/ESH guidelines [15]
  • Asian or African descent
  • Do not meet the level of physical activity recommended by the WHO based on self-report [15]
  • Non-medicated patients or patients using a maximum of 2 antihypertensive drugs

Exclusion criteria

• • Functional or mental limitation limiting the correct execution of an exercise bout

  • History of ischemic stroke, autonomic neuropathy, cardiovascular, renal, or pulmonary disease by self-report
  • Diabetes type I or II
  • Pregnancy
  • The presence of exercise induced signs of myocardial ischemia or complex ventricular arrhythmia during CPET
  • Patients using three or more antihypertensive drugs or patients with resistant hypertension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

60 participants in 3 patient groups

isometric handgrip exercise

Active Comparator group

Description:

4x2 minutes of isometric handgrip exercise

Treatment:

Behavioral: Exercise

control

No Intervention group

Description:

seated control session

Aerobic exercise

Experimental group

Description:

aerobic exercise at 40-60% HRres

Treatment:

Behavioral: Exercise