Hyperthermia and High Dose Rate Radiation Therapy in Treating Patients With Recurrent Prostate Cancer After Radiation

Sidney Kimmel Cancer Center at Thomas Jefferson University

Status

Active, not recruiting

Conditions

Recurrent Prostate Carcinoma

Treatments

Radiation: High-Dose Rate Brachytherapy

Other: Laboratory Biomarker Analysis

Procedure: Hyperthermia Treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT02899221

JT 8400 (Other Identifier)

16D.246

Details and patient eligibility

About

This phase I trial studies the side effects and best way to give hyperthermia and high dose rate radiation therapy in treating patients with prostate cancer that has come back after prior radiation treatment. Radiation therapy, such as high dose rate brachytherapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Hyperthermia therapy may make tumor cells more sensitive to the effects of radiation therapy by heating them to several degrees above normal body temperature. Giving hyperthermia and high dose rate radiation therapy may work better in treating patients with recurrent prostate cancer after radiation.

Full description

PRIMARY OBJECTIVES:

I. To assess the safety and feasibility of combined single fraction high dose rate (HDR) brachytherapy followed immediately by interstitial hyperthermia treatment of radio-recurrent prostate cancer.

SECONDARY OBJECTIVES:

I. To assess long-term toxicity. II. To provide a preliminary assessment of efficacy. III. To obtain blood for future analysis of immune response to combined radiation therapy and hyperthermia.

OUTLINE:

Patients undergo high dose rate brachytherapy for 15-30 minutes. Immediately after radiation therapy (no longer than 90 minutes), patients undergo interstitial hyperthermia treatment for up to 60 minutes.

After completion of study treatment, patients are followed up at 1 week, 1 month, and every 3 months for 2 years, every 6 months for 3 years and annually thereafter.

Enrollment

3 patients

Sex

Male

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male age >= 18 years
Karnofsky performance status > 70%
Expected survival of at least 3 years
Informed consent signed by the subject
PSA blood test within 60 days prior to registration
Prostate biopsy with Gleason score and TNM staging within one year prior to registration
No evidence of metastasis on computed tomography (CT) or magnetic resonance imaging (MRI) of the pelvis within 120 days prior to registration
No evidence of metastasis on bone scan within 120 days prior to registration
Within 60 days prior to registration, hematologic minimal values: absolute neutrophil count > 1,500/mm^3
Within 60 days prior to registration, hematologic minimal values: hemoglobin > 8.0 g/dl
Within 60 days prior to registration, hematologic minimal values: platelet count > 100,000/mm^3
Men of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months after completion of treatment
Histologically proven persistent or recurrent adenocarcinoma of the prostate following prior external beam radiation therapy or brachytherapy
Prior androgen deprivation or chemotherapy is allowed if discontinued at least 30 days prior to enrollment
Concurrent disease - patients under treatment for concurrent medical conditions will be eligible for protocol treatment if, in the opinion of the physician responsible for hyperthermia treatment that the concurrent medical condition will neither interfere with the process of the treatment or patient assessments nor add significantly to the risks or complications of the treatment

Exclusion criteria

History of urological surgery or procedures predisposing to genitourinary (GU) complications after radiation, i.e., anastomoses, stricture repair, transurethral resection, etc. (will be determined by radiation oncologist)
Prior thermal ablative therapy for prostate cancer (e.g. high-intensity focused ultrasound [HIFU] or cryoablation)
Documented distant metastatic disease
Patient with other co-morbidities that in the opinion of the treating physician would be a contra-indication to protocol participation (e.g. inflammatory bowel disease)
Mental incompetence or criminal incarceration