Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Bronchiectasis

Belfast Health and Social Care Trust

Status and phase: Unknown; Phase 2

Conditions: Bronchiectasis

Treatments: Other: Isotonic saline; Other: Hypertonic saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01112410

09023JB-OPMS

Details and patient eligibility

About

The investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable bronchiectasis.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non CF Bronchiectasis
• 18-80 years
• FEV1 less than 90%
• Chronic sputum production
• Clinical stable

Exclusion criteria

• Intolerance to HTS
• Use of HTSaline or antibiotics 14 days prior to study
• Clinically unstable
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind