Hyperventilation in Patients With Chronic Low Back Pain (HELBP)

Hasselt University

Status: Enrolling

Conditions: Hyperventilation Syndrome; Low Back Pain, Recurrent

Treatments: Behavioral: assessment of hyperventilation, postural control and psychological behavior

Study type: Interventional

Funder types: Other

Identifiers

NCT04074798

CME ZOL - CTU2019078

Details and patient eligibility

About

Low back pain (LBP) is the leading cause of disability worldwide. Impaired postural control is a key factor in the development and maintenance of LBP. Moreover, the prevalence of LBP is associated with impairments in diaphragm function, symptoms of dyspnea, and dysfunctional breathing. However, the association between LBP (and more specifically postural control) and hyperventilation remains unknown. The main objective of this project is to investigate whether the presence of recurrent non-specific LBP is related to the presence of hyperventilation, when classified either objectively by decreased carbon dioxide values (demonstrating hypocapnia) or by symptoms while showing normal carbon dioxide values. Moreover, the investigators will explore whether psychosocial factors play a role in this relation. Subsequently, the investigators will examine whether hyperventilation in LBP patients is related to impaired postural control, and more specifically to a decreased postural contribution of the diaphragm.

Enrollment: 90 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Patients:

• Chronic primary low back pain (>12 weeks) as diagnosed by a medical doctor

Inclusion Criteria Healthy controls:

• No low back pain

Exclusion Criteria:

• Insufficient understanding of Dutch language
• Previous spinal surgery
• Chronic Obstructive Lung Disease, Interstitial Lung Disease, pulmonary vascular disease, asthma except for exertional asthma
• Acute cardiovascular or gastrointestinal disorders
• Neuromuscular disease interfering with normal lower limb or trunk functioning
• Acute pain or secondary chronic pain
• Pregnant and lactating women
• Major psychiatric conditions
• Acute lower limb problems
• Vestibular disorders

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 2 patient groups

Patients with low back pain

Active Comparator group

Treatment:

Behavioral: assessment of hyperventilation, postural control and psychological behavior

Healthy controls

Sham Comparator group

Treatment:

Behavioral: assessment of hyperventilation, postural control and psychological behavior