Hypnotic and Anti-nociceptive Components of Magnesium

University of Liege

Status and phase: Unknown; Phase 4

Conditions: Anesthesia

Treatments: Drug: Placebo; Drug: Magnesium sulfate IV

Study type: Interventional

Funder types: Other

Identifiers

NCT05005494

MG-Entropy

Details and patient eligibility

About

The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol.

Full description

The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol. To achieve this, the investigators will analyse the effect of magnesium on the brain concentrations of propofol required to achieve a State Entropy value between 50-60, which corresponds to the recommended depth of anaesthesia. Our study will also evaluate the intraoperative anti- nociceptive effect of magnesium using pupillometry and its two indices, PPI and PRD

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult > 18 years
• Patients of both sexes
• Any patient scheduled for thyroidectomy at the University Hospital of Liege

Exclusion criteria

• Heart failure with left ventricular ejection fraction < 35
• Renal insufficiency (clearance < 40 mL/min)
• Neuromuscular diseases
• Atrioventricular block
• Pregnancy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups, including a placebo group

Magnesium sulfate IV

Active Comparator group

Description:

10 patients scheduled for thyroidectomy

Treatment:

Drug: Magnesium sulfate IV

Placebo

Placebo Comparator group

Description:

10 patients scheduled for thyroidectomy

Treatment:

Drug: Placebo