Hypo-hydration Mood and Cognition

Swansea University

Status: Unknown

Conditions: Cognitive Change; Mood

Treatments: Biological: Salt with / without water

Study type: Interventional

Funder types: Other

Identifiers

NCT03948230

DB-0519

Details and patient eligibility

About

Recently changes in mood and cognition have been reported following minor reductions in hydration status. The aim is to explore that such changes in part at least reflect placebo response; therefore the consumption of plain or coloured water will be compared in drinks designed to differ in their ability to rehydrate.

Full description

162 individuals will be subject to a temperature of 30°C for three hours, and mood and cognition monitored. Randomly on two occasions they will consume no drink or 300ml of plain or red colored water. In addition they will take a capsule containing sodium chloride or a placebo. Mood will be monitored using visual analogue scales and a battery of cognitive tests will be completed on three occasions: attention, episodic and working memory, reactions times. Urine osmolality will be measured at the beginning and end of the study and changes in body mass will be recorded. Changes in functioning will be related to the nature of the drink and changes in osmolality and body mass.

Enrollment: 162 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 30 years
• Non-smokers
• BMI < 30
• By self-report in good health
• Not taking medication for any psychological or other health disorder.

Exclusion criteria

• Do not meet inclusion criteria

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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162 participants in 6 patient groups, including a placebo group

Sodium chloride / Water

Active Comparator group

Description:

300mg sodium chloride consumed in a capsule on two occasions with 300ml water

Treatment:

Biological: Salt with / without water

Sodium chloride / no water

Active Comparator group

Description:

300 mg sodium chloride consumed

Treatment:

Biological: Salt with / without water

Sodium chloride / colored water

Active Comparator group

Description:

300mg sodium chloride consumed in a capsule on two occasions with 300ml coloured water

Treatment:

Biological: Salt with / without water

Placebo / water

Placebo Comparator group

Description:

Placebo consumed in a capsule on two occasions with 300ml water

Treatment:

Biological: Salt with / without water

Placebo / no water

Placebo Comparator group

Description:

Placebo capsule consumed

Treatment:

Biological: Salt with / without water

Placebo / coloured water

Placebo Comparator group

Description:

Placebo consumed in a capsule on two occasions with 300ml colored water

Treatment:

Biological: Salt with / without water