Hypodontia and Ovarian Cancer

University of Aarhus

Status: Unknown

Conditions: Hypodontia; Breast Cancer; Colon Cancer; Ovarian Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01470235

Hypodontovariancancer2011

Details and patient eligibility

About

The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).

If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• confirmed suspicion of ovarian cancer.

Exclusion criteria

• suspicion of ovarian cancer disproved.

Trial design

200 participants in 3 patient groups

Ovarian Cancer

Description:

Women treated for ovarian cancer at the departments of obstetrics and gynecology, Aarhus University Hospital and Rigshospitalet, Copenhagen. Expected recruitment: 200

Control patients

Description:

Women referred to the departments of obstetrics and gynecology in Aarhus University Hospital and Rigshospitalet, Copenhagen on benign indication. Expected recruitment: 200.

HBOC/HNPCC

Description:

Patients registered in the large Danish Register of HBOC( hereditary breast and ovarian cancer) and HNPCC (hereditary nonpolyposis colorectal cancer). Expected recruitment: 200.