Hypofractionated Intensity Modulated Chemoradiotherapy to Treat Locally Advanced Non-Small Cell Lung Cancer

National University Health System (NUHS)

Status and phase

Unknown

Phase 2

Conditions

Stage III Non-Small Cell Lung Cancer

Treatments

Radiation: Dose escalated, accelerated, hypofractionated radiotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00938418

B/09/108

Details and patient eligibility

About

Locally advanced non-small cell lung cancer can be treated successfully with chemotherapy and radiation. However, the cure rate is low.

This study is carried out to find out whether giving radiotherapy at a higher dose over fewer treatment sessions with intensity modulated radiotherapy (IMRT) can improve the treatment outcome.

This study aims to recruit 43 patients from National University Hospital and Tan Tock Seng Hospital over a period of about 2 years.

Enrollment

43 estimated patients

Sex

All

Ages

21 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Pathologically proven (either histologic or cytologic) diagnosis of Stage IIIA or IIIB non-small cell lung cancer; excluding patients with N3 disease based on supraclavicular or contralateral hilar adenopathy, or significant pleural / pericardial effusion.

Exclusion criteria

Patients for whom treatment is planned with a maximum dose of ≥ 66 Gy to the ipsilateral brachial plexus
Greater than minimal, exudative, or cytologically positive pleural effusions
≥ 10% weight loss within the past month
Prior invasive malignancy (with exceptions)
Prior radiotherapy to the region of the study cancer
Significant co-morbidities
Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
Known allergic reactions to components of planned chemotherapy regimen