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In this study, participants will have standard Androgen Deprivation Therapy and undergo standard external beam radiation therapy to the prostate and at-risk lymph nodes by Intensity Modulated Radiation Therapy. The subsequent *boost* radiation therapy to the prostate alone will be given using the CyberKnife, rather than using the standard Intensity Modulated Radiation Therapy. This study will also see how CyberKnife affects the quality of the participant's life.
Full description
In this study, participants will have standard androgen deprivation therapy and undergo standard radiation therapy to the prostate and at-risk lymph nodes by intensity-modulated radiation therapy (IMRT). The subsequent *boost* radiation therapy to the prostate alone will be given using the CyberKnife, rather than using the standard Intensity Modulated Radiation Therapy. This study will also see how CyberKnife affects the quality of the participant's life.
Enrollment
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Volunteers
Inclusion criteria
Histologically proven adenocarcinoma of the prostate
Clinical stage (American Joint Committee on Cancer 7th Edition)
a. T-stage determined by physical exam (Digital Rectal Exam Required)
i. MRI findings (e.g. extracapsular extension) can be used to determine T-staging
b. N-stage determined using abdominopelvic CT scan and/or MRI
c. M-stage determined by physical exam, CT and/or MRI, and bone scan (must be M0, excepting Lymph nodes)
Please note: a SPECT bone scan including a CT of the abdomen and pelvis or an F18 Fluciclovine PET/CT fulfills protocol criteria for both the abdominopelvic CT and bone scan.
Patients must belong to one of the following risk groups:
OR
Patient is receiving, or planning to receive standard androgen deprivation therapy and initial IMRT to the prostate and positive or at-risk lymph nodes.
Prostate volume greater than 20 cc and less than 100 cc
Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patient has agreed to complete questionnaires
Signed IRB approved informed consent
Patient eligible to have an MRI
Must be able to tolerate the confinement of an MRI procedure
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
35 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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