Hypofractionated Stereotactic Radiotherapy for Patients With Recurrent High Grade Glioma

Istituto Clinico Humanitas

Status: Completed

Conditions: Recurrent High Grade Glioma

Treatments: Drug: Radiosensitive therapy; Radiation: IMRT with or without radiosensitive therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02567539

1394

Details and patient eligibility

About

The study is aimed to evaluate efficacy and safety of re-irradiation for patients with recurrent high grade gliomas after other treatment.

Full description

Investigators designed this study of a re-irradiation with single radiosurgery or hypofractionated intensity modulated radiation therapy (IMRT) with or without temozolomide.

Objective of the study is evaluating efficacy and safety of re-irradiation for patients with recurrent high grade gliomas after other treatment.

Enrollment: 88 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Karnosky performance status (KPS) ≥70
• Patients aged >70 years with KPS ≥80
• Histopathologically confirmed grade III-IV glioma
• Estimated survival ≥ 3 months
• Any Tumor volume
• Unifocal tumor
• Interval time from previous radiotherapy ≥ 6mesi
• Normal liver, Kidney and bone marrow function
• Written informed consent

Exclusion criteria

• KPS < 70
• Multifocal tumor
• Other primary cancer
• Pregnant women

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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88 participants in 1 patient group

Recurrent high grade glioma

Experimental group

Description:

IMRT with or without radiosensitive therapy

Treatment:

Radiation: IMRT with or without radiosensitive therapy

Drug: Radiosensitive therapy