Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management

University of Brawijaya

Status: Enrolling

Conditions: Endometrial Cancer; Cervical Cancer

Treatments: Procedure: Ganglion Impar Block; Procedure: Superior Hypogastric Plexus Block

Study type: Interventional

Funder types: Other

Identifiers

NCT05427058

UB_WWN01

Details and patient eligibility

About

This study compared the efficacy and safety of superior hypogastric plexus block and ganglion impar block procedures on the management of pelvic and perineal cancer pain in patients with cervical and endometrial cancer

Full description

Superior hypogastric plexus block is a commonly used method for the management of pelvic and perineal pain due to cancer, this procedure uses a transdiscal approach at the level of the L5-S1 vertebrae by injecting 5 ml of 1% lidocaine + 10 ml of 96% alcohol and confirmed by C-arm.

Compared with the ganglion impar block procedure using a trans-sacrococcygeal approach by injecting 4 ml of 1% lidocaine + 6 ml of 96% alcohol and confirmed by C-arm. The aim of this study was to compare the efficacy and safety of the ganglion impar block procedure against the superior hypogastric plexus block which is commonly used in the management of pelvic and perineal pain due to cervical and endometrial cancer.

Enrollment: 36 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Unbearable cancer pain that is resistant to WHO (World Health Organization) pain ladder at least 2 weeks medication
• The patient is tired of taking medication orally or complications of current medication (respiratory depression, nausea, vomiting, opioid-induced constipation, gastrointestinal disturbances)
• Patients with pelvic floor pain diagnosed by a (Fellow of Interventional Pain Practice) FIPP-certified pain specialist
• Patients with pain in the perineum diagnosed by a FIPP-certified pain specialist
• Numerical Rating Scale >4
• >18 years old
• Able and willing to sign an informed consent

Exclusion criteria

• Refuse to be included in the research
• Blood clotting disorders (including taking anticoagulant drugs)
• Local infection in the area of action
• Loss to follow up

Drop-out Criteria:

• Loss to follow up
• Intervention complications occur
• Failed intervention

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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36 participants in 2 patient groups

group 1: superior hypogastric plexus block group

Active Comparator group

Description:

Device: C-arm fluoroscopic device Drug: lidocaine + alcohol

Treatment:

Procedure: Superior Hypogastric Plexus Block

group 2: ganglion impar block group

Experimental group

Description:

Device: C-arm fluoroscopic device Drug: lidocaine + alcohol

Treatment:

Procedure: Ganglion Impar Block