Hypomagnesemia Associated With Proton-Pump Inhibitor Use (PPI_HypoMg)

Changi General Hospital

Status: Completed

Conditions: Seizures; Hypokalemia; Arrhythmias, Cardiac; Proton Pump Inhibitor Adverse Reaction; Hypocalcemia; Hypomagnesemia

Treatments: Drug: proton pump inhibitor use

Study type: Observational

Funder types: Other

Identifiers

NCT04426994

PPI HypoMg

Details and patient eligibility

About

Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors

Enrollment: 211,672 patients

Sex: All

Ages: 14 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted with hypomagnesemia (cases)
• Patients prescribed with proton pump inhibitors (controls)

Exclusion criteria

• Patients prescribed with less than three months duration of proton pump inhibitors (controls)

Trial design

211,672 participants in 2 patient groups

Case

Description:

Patients admitted with hypomagnesemia are evaluated for proton pump inhibitor use and likelihood of hypomagnesemia due to proton pump inhibitor use

Treatment:

Drug: proton pump inhibitor use

Control

Description:

Patients on long-term proton pump inhibitor without documented hypomagnesemia

Treatment:

Drug: proton pump inhibitor use