Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours (MissPerfeCT)

University Hospital Muenster

Status: Completed

Conditions: Acute Ischemic Stroke

Treatments: Diagnostic Test: hypoperfusion-hypodensity mismatch

Study type: Observational

Funder types: Other

Identifiers

NCT04277728

100001

Details and patient eligibility

About

Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the study is to evaluate whether a hypodensity on native CT within the virtually entire area of hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with >70% specificity and >85% positive predictive value.

Enrollment: 689 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute ischemic stroke
• evidence of acute intracranial vessel occlusion (any supratentorial proximal or peripheral artery of the anterior cerebral artery, middle cerebral artery or posterior cerebral artery territory) by CT hyper dense thrombus and/or CTangiography vessel occlusion and/or by ischemic perfusion deficit
• evidence for acute ischemic perfusion deficit, i.e. acute symptoms attributable to ischemic CT perfusion lesion
• complete native CT and CTperfusion performed on admission
• sufficient CT and CTperfusion quality for judgement of acute ischemic hypodensity
• known time of symptom onset.

Exclusion criteria

• None