Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients

Yonsei University

Status: Completed

Conditions: Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT02565589

NK_ICU_healthy

Details and patient eligibility

About

To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.

Full description

Blood samples were collected < 24 hours after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. NK cell activities, cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured.

Enrollment: 48 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ICU patients
• For healthy controls: nondiabetic and nonobese subjects

Exclusion criteria

• For healthy controls: diabetes; history/presence of significant metabolic disease; pregnancy or breast-feeding; acute or chronic infection; liver disease; kidney disease; gastrointestinal disease; subjects taking any drugs or supplements

Trial design

48 participants in 2 patient groups

ICU patient

Description:

Critically ill patients who were enrolled less than 24 hours after ICU admission.

Control

Description:

Age-, sex-, and BMI-matched healthy subjects.