Hypotension After Anesthetic Induction with Remimazolam in Elderly

Kangbuk Samsung Hospital

Status: Completed

Conditions: Hypotension

Treatments: Drug: Bolus of remimazolam; Drug: Continuous infusion of remimazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT05538741

RMZ_bolcon_old

Details and patient eligibility

About

Even though remimazolam is known to be safely administered without hemodynamic instability, hypotension is the one of the common side effects of remimazolam. Because elderly patients are susceptible to hypotension due to old age, multimodality, and multiple medications, hypotension can be harmful in elderly patients. Remimazolam can be administered either bolus or continuous for anesthetic induction. In our study the investigators aimed to compare the incidence of hypotension after anesthetic induction using remimazolam by bolus injection and continuous infusion in elderly patients.

Enrollment: 62 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elderly patients with age over 60 years old
• scheduled for elective surgery under general anesthesia
• American Society of Anesthesiology Physical Status I-III

Exclusion criteria

• Arrhythmia
• Liver dysfunction
• Kidney dysfunction
• Uncontrolled hypertension
• Uncontrolled diabetes mellitus
• Allergic to benzodiazepines
• Heart failure
• Drug intoxication
• Alcoholics
• Cognitive dysfunction
• Unable to understand and consent voluntarily

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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62 participants in 2 patient groups

Bolus

Experimental group

Description:

Remimazolam bolus injection for 20 seconds

Treatment:

Drug: Bolus of remimazolam

Continuous

Active Comparator group

Description:

Remimazolam continuous infusion

Treatment:

Drug: Continuous infusion of remimazolam