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Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness

The University of Texas System (UT) logo

The University of Texas System (UT)

Status

Completed

Conditions

Prehypertension
Stage-1 Hypertension

Treatments

Dietary Supplement: Add 4 servings fruit
Dietary Supplement: Non-fat dairy

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.

Enrollment

49 patients

Sex

All

Ages

35 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Prehypertension or stage-1 hypertension

Exclusion criteria

  • Consume > 3 servings of dairy or fruit per day
  • Strenuous physical activity > 3 time per week
  • Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
  • Taking cardiovascular-acting drugs
  • Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

49 participants in 2 patient groups

Dairy
Experimental group
Description:
Add 4 daily servings of non-fat dairy to diet for a period of 4 weeks
Treatment:
Dietary Supplement: Non-fat dairy
Fruit
Active Comparator group
Description:
Add 4 daily servings of fruit to diet, remove all dairy from diet for a period of 4 weeks
Treatment:
Dietary Supplement: Add 4 servings fruit

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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