Hypothermia and Hemostasis After Cardiac Arrest

University of Aarhus

Status

Unknown

Conditions

Hemostasis

Heart Arrest

Coagulants

Hypothermia

Treatments

Other: Therapeutic hypothermia

Study type

Interventional

Funder types

Other

Identifiers

NCT02258360

PROID7005

Details and patient eligibility

About

This is a sub-study to the Time-differentiated Therapeutic Hypothermia (TTH48, ClinicalTrials.gov Identifier: NCT01689077). TTH48 compares 24 with 48 hours of therapeutic hypothermia at a target temperature of 32-34°C in survivors of out-of-hospital cardiac arrest.

The overall aim of this sub-study is to examine the hemostasis in patients resuscitated after cardiac arrest and treated with 24 and 48 hours of therapeutic hypothermia

Our specific aims are:

To investigate the whole blood coagulation using the rotational thromboelastometry.
To investigate the function of platelets

Enrollment

82 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Out of hospital cardiac arrest of presumed cardiac cause
Return of spontaneous circulation (ROSC)
Glasgow Coma Score < 8
Age > 18 years and < 80 years

Exclusion criteria

> 60 minutes from the circulatory collapse to ROSC
Time interval > 4 hours from cardiac arrest to initiation of therapeutic hypothermia
Terminal illness
Coagulation disorder
Unwitnessed asystolia
Cerebral performance category 3-4 before the cardiac arrest
Severe persistent cardiogenic shock
Pregnancy
Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment)
New apoplexy or intracerebral hemorrhage
Lack of consent from the relatives
Lack of consent from the GP
Lack of consent from the patient if he/she wakes up and is relevant