Hypoxia, Appetite, and Energy Intake in Young Female Adults

University of Ottawa

Status: Enrolling

Conditions: Energy Intake; Altitude; Hypoxia; Appetite

Treatments: Other: Normoxia; Other: Hypoxia (simulated altitude of 5000 meters above sea-level)

Study type: Interventional

Funder types: Other

Identifiers

NCT06912230

H-06-18-837

Details and patient eligibility

About

The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are:

• Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake?
• Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake.

Participants will:

• Visit the laboratory for a preliminary screening session to assess eligibility.
• Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber.
• Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.

Enrollment: 10 estimated patients

Sex: Female

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• English or French speaking
• Ability to provide informed consent

Exclusion criteria

• History or evidence of chronic disease
• Current use of hypolipemic medication
• Current use of hormonal contraceptives
• Current use of antidepressants
• Current use of anticoagulants
• Ongoing smoking status
• Experiencing pregnancy, puerperium, or irregular menstrual cycles

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Normoxia

Experimental group

Treatment:

Other: Normoxia

Hypoxia (simulated altitude of 5000 meters above sea-level)

Experimental group

Treatment:

Other: Hypoxia (simulated altitude of 5000 meters above sea-level)