Hypoxic Burden and Sleepiness in Treated OSA Patients (MWTBH)

Civil Hospices of Lyon

Status: Completed

Conditions: Obstructive Sleep; OSA

Treatments: Other: Impact of hypoxic burden on objective and subjective sleepiness in patients treated for Obstructive Sleep apnea

Study type: Observational

Funder types: Other

Identifiers

NCT06700837

23-5474

Details and patient eligibility

About

The Maintenance of Wakefulness Test (MWT) is widely used to objectively assess sleepiness and make safety-related decisions and Epworth Sleepiness Scale (ESS) is the most used scale used to assess subjective sleepiness in sleep medicine.

Besides Obstructive Sleep Apnea measures are rapidly evolving and conventional measures such as apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) are increasingly being supplemented by measures of hypoxia such as hypoxic burden.

Residual AHI in treated OSA have limited predictive value for objective sleepiness. Therefore it seems particularly relevant to identify other predictors of both subjective and objective sleepiness.

This study aims at studying the influence of hypoxic burden as measure of both subjective or objective sleepiness.

We hypothesize that impaired nocturnal oxygenation might influence brain functioning during wakefulness and result in sleepiness as assessed by ESS and MWT.

Enrollment: 141 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• OSA hospitalised to undergo both polysomnography (PSG) and the 40-min MWT in the Center for Sleep Medicine and Respiratory Disease, Lyon Academic Hospital from September 2017 to March 2020.

Exclusion criteria

• • age <18 years
• refusal to participate in the study
• diagnosis of central disorder of hypersomnolence
• missing data on the MWT
• Epworth Sleepiness Scale (ESS)
• apnea-hypopnea index (AHI).

Trial design

141 participants in 1 patient group

Hypoxic burden and Sleepiness in treated OSA patients

Description:

In this retrospective study, we reviewed the files of all patients with OSA hospitalised to undergo both polysomnography (PSG) and the 40-min MWT in the Center for Sleep Medicine and Respiratory Disease, Lyon Academic Hospital from September 2017 to January 2020. All these patients underwent a full night polysomnography.

Treatment:

Other: Impact of hypoxic burden on objective and subjective sleepiness in patients treated for Obstructive Sleep apnea