Ibuprofen in Migraine Patients

Kecioren Education and Training Hospital

Status and phase

Completed

Phase 4

Conditions

Migraine Without Aura

Treatments

Drug: Dexketoprofen

Drug: Ibuprofen 400 mg

Study type

Interventional

Funder types

Other

Identifiers

NCT04533568

66175679

Details and patient eligibility

About

In this study, the investigators planned to compare the effectiveness of an intravenous ibuprofen against an intravenous dexketoprofen among patients (18-65 years) who were admitted to the emergency department (ED) with acute migraine-related headaches and diagnosed migraine without aura.

In this study, patients who presented with migraine-related headache to emergency departments will be included in this study. Two different therapy option are created; first, 400mg intravenous ibuprofen with 10mg intravenous metoclopramide Hcl , second, 50 mg intravenous dexketoprofen with 10mg intravenous metoclopramide Hcl.

Patients's headache scores will be measured with visual analog score (VAS) at the pretreatment and post-treatment periods (0. minutes, 30. minutes, and 60. minutes.) 60 minutes after treatment, as a rescue therapy, 100mg tramadol will be given to patients whose headache score does not decrease by more than 50% from pretreatment-VAS score.

Enrollment

160 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All the patients aged 18-65 years who had been admitted to the ED for headaches and diagnosed acute migraine-related headache according to the International Classification of Headache Disorders-2018 edition
Patients whose pre-treatment VAS scores are more than 40 point.
Patients who give written and verbal consent to include study.

Exclusion criteria

Patients had taken any analgesic drugs or drugs for migraine prophylaxis in the last 6 hours
Patients had a history of allergy to any of the drugs used in this study
Patients used any anticoagulant-agents,
Patients had bleeding diathesis
patients were pregnant,
patients were breastfeeding mothers
Patients who had chronic heart disease, chronic liver disease, and chronic kidney disease
Patients had peptic ulcer
Patients had a history of acute akathisia or acute dystonia to metoclopramide hcl