Ibuprofen Use on Post-operative Pain Following Cholecystectomy

Giresun University

Status and phase: Completed; Phase 4

Conditions: Acute Post-operative Pain

Treatments: Drug: Acetaminophen 100 MG/ML; Drug: Ibuprofen 400 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT06478758

KAEK-230

Details and patient eligibility

About

In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen.

Full description

Ibuprofen is a widely used NSAID that has antipyretic, analgesic, and anti-inflammatory effects. In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.The participants in this study were randomized into two groups. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen. The investigators recorded demographic data including gender, age, ASA, BMI, duration of anesthesia and surgery, poNV, LOS, VAS scores and opioid consumption postoperatively.

Enrollment: 71 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA grade I-II patients
• Aged 18-65 years

Exclusion criteria

• History of allergies or hypersensitivity to the aforementioned agents
• Renal, hepatic or gastrointestinal disease
• Significant cognitive impairment
• Recent use of long-term nonsteroid anti-inflammatory and opioids
• Oral anticoagulant use or known bleeding disorders
• Diabetes or any other neuropathic diseases
• Pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

71 participants in 2 patient groups

Acetaminophen group

Active Comparator group

Description:

The acetaminophen group (n=35) received 1000 of mg acetaminophen intravenously in 100 mL saline at the end of the cholecystectomy.

Treatment:

Drug: Acetaminophen 100 MG/ML

Ibuprofen group

Experimental group

Description:

The ibuprofen group (n=36) was administered 800 mg of ibuprofen at the end of the cholecystectomy.

Treatment:

Drug: Ibuprofen 400 mg