Identification in Obese Patients of the Mechanism Involved in Intramuscular Lipid Accumulation

University Hospital Center (CHU)

Status: Completed

Conditions: Hyperlipidemia; Insulin Resistance; Obesity

Treatments: Other: Lipid accumulation analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT01644942

8193

Details and patient eligibility

About

The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.

Full description

Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.

Enrollment: 33 patients

Sex: Male

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2
• Patients who do not practice physical exercise (Voorips index < 9)
• Age between 40 and 70 years- Male gender
• Fast blood glucose <1,10 g/l and no hypoglycemic treatment
• Signed informed consent
• Social security affiliation
• Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen
• Normal biological tests
• Non smoking persons

Exclusion criteria

• Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests
• Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory.
• Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy
• Allergy to local anaesthetic

Trial design

33 participants in 2 patient groups

Insulin sensitive patients

Other group

Treatment:

Other: Lipid accumulation analysis

Insulin resistant patients

Other group

Treatment:

Other: Lipid accumulation analysis