Identification of Biomarkers for Obstructive Sleep Apnoea Syndrome

New University of Lisbon

Status: Completed

Conditions: Obstructive Sleep Apnoea Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02043483

FCM-

Details and patient eligibility

About

Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus). Until now, no molecular markers for this physiopathological connection have been identified.

This project aims to determine non-invasive biomarkers that may allow better comprehension of the metabolic consequences of OSAS, as well as assess the effect of Continuous positive airway pressure (CPAP) on these metabolic parameters.

This project will integrate the clinical, metabolic, genetic/proteomic and biologic systems to further explore the mechanisms behind OSAS, as well as the effect of the treatment with CPAP.

Enrollment: 120 estimated patients

Sex: Male

Ages: 25 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male
• 25-60 years
• Mild/Moderate/Severe OSAS

Exclusion criteria

• Female
• Other sleep disorders
• Previous CPAP therapy
• Type 1 diabetes mellitus
• Familiar Dyslipidemia
• Severe organ pathology
• Acute disease

Trial design

120 participants in 2 patient groups

CPAP

Description:

Patients with moderate/severe OSAS will be treated with CPAP

Control

Description:

Patients with snoring will not be subject to treatment with CPAP