Identification of Biomarkers of Attention Deficit Disorder With or Without Hyperactivity (ADHD) by a Metabolomic Approach in Children (METHADA)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Adhd

Treatments: Other: Metabolomic approach

Study type: Observational

Funder types: Other

Identifiers

NCT03436017

RIPH3-RNI17/METHADA

Details and patient eligibility

About

Attention-deficit with or without hyperactivity disorder (ADHD) is a real health public concern. No easy-use diagnosis tool are available. Metabolomic approaches has brought very usefull data in others neurological diseases like amyotrophic lateral sclerosis or autism spectrum disorder, as we had shown in previous studies. Targeting on neurotransmitter pathways involving in ADHD, metabolomic screening could help to enhance our diagnosis power to better help numerus of children. We propose to study the phenylalanine and the tyrosine pathways with a multimodal metabolomic approach, in easy-available biological fluid (blood and urine), in child or adolescent suspected of ADHD. Our objectives are: 1- to determine a specific metabolomic signature of ADHD 2- to compare the diagnostic value of this metabolomic signature with the reference methodology for ADHD diagnosis, as now practiced in our reference center for learning troubles.

Enrollment: 89 patients

Sex: All

Ages: 6 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Child or adolescent with symptoms of attention disorders and / or hyperactivity
• aged from 6 to 15 years old

Exclusion criteria

• Failure or refusal of all or part of the multidisciplinary evaluation (medical and / or neuropsychological assessments and / or biological assessments)
• Identification of an intercurrent condition likely to have an impact on metabolomic analyzes (acute infection, fever, etc.)
• Parents or legal guardians opposed to data processing

Trial design

89 participants in 2 patient groups

ADHD

Description:

Patient with ADHD diagnosis criterion. The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach

Treatment:

Other: Metabolomic approach

non ADHD

Description:

Patient with symptom of hyperactivity and/or attention deficiency but without ADHD diagnosis criterion. The aim is the identification of Biomarkers of ADHD by a Metabolomic Approach.

Treatment:

Other: Metabolomic approach