Identification of Clostridium Butyricum and Clostridium Neonatal in the Digestive Microbiota of Premature Infants Before 34 Weeks and Developing or Not Ulcerative Necrotizing Enterocolitis (NEC) During Hospitalization (ECUN-2)

Centre Hospitalier Universitaire de Nīmes

Status: Active, not recruiting

Conditions: Necrotizing Enterocolitis

Treatments: Other: Stool sample

Study type: Observational

Funder types: Other

Identifiers

NCT04584320

NIMAO/2019-01/MdM01

Details and patient eligibility

About

The study investigators hypothesize that Clostridium butyricum and Clostridium neonatal will be more frequently found in the stool of preterm infants with ulcerative necrotizing enterocolitis compared to healthy matched control infants. Systematic daily samples should show that the kinetics of colonization precedes the onset of the pathology. Finally, the systematic ecological survey at the time of infection could help understand the mode of acquisition and transmission of these bacteria.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Premature newborn with a term of birth ≤ 34 weeks of gestation admitted to the neonatology department at the CHU of Nîmes.
• Affiliated or beneficiary of a health insurance plan.
• Newborn whose parents received informed information about the study and did not express their opposition to their child's participation in the study.

Exclusion criteria

• Newborn with malformative digestive pathology
• Newborn baby participating in another category 1 trial

Trial design

40 participants in 2 patient groups

Premature neonates with necrotizing enterocolitis

Treatment:

Other: Stool sample

Premature neonates without necrotizing enterocolitis

Treatment:

Other: Stool sample