Identification of Corticomedullary Differentiation Along Different Stage of Pregnancy

Clalit Health Services

Status: Unknown

Conditions: Nephropathy

Study type: Observational

Funder types: Other

Identifiers

NCT02193516

MMC1413-0250CTIL

Details and patient eligibility

About

Corticomedullary differentiation (CMD) abnormality (absent/reversed) is a parameter that can indicate possible nephropathy. The evolution of CMD across gestation had not been well established. Devrendt et al demonstrated the presence of CMD in all fetuses older then 20 weeks. In our study we would like to determine the exact timing of it's sonographic visualisation. This is a prospective study recruiting women between 14-24 week gestation during routine ultrasound screening. A midsagittal image of each kidney will be taken by a single sonographer and examined for the presence of the CMD by two other sonographers blinded to gestational age.

Enrollment: 330 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• pregnant women 14-24 weeks
• singleton pregnancy
• Appropriate for gestational age fetuses
• well dated pregnancy

Exclusion criteria

• family history of renal disease
• small /large for gestational age fetuses
• known structural anomalies
• unknown dating