Identification of Gene and Protein Markers of Kidney Injury in Aminoglycoside-treated Children

Virginia Commonwealth University (VCU)

Status: Completed

Conditions: Infection; Renal Dysfunction

Treatments: Drug: aminoglycoside

Study type: Observational

Funder types: Other

Identifiers

NCT00308906

Aminoglycoside Waste Specimen

Details and patient eligibility

About

The purposes of this study are to identify potential gene and protein markers of aminoglycoside-induced kidney injury in infants, children and adolescents treated with aminoglycoside antibiotics.

Enrollment: 166 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: (1) Hospitalized male and female newborns, infants, children and adolescents (ages birth to 18 years) with a diagnosis of suspected or proven bacterial sepsis, meningitis or other indication necessitating aminoglycoside therapy (2) hospitalized and outpatient newborns, infants, children and adolescents (ages birth to 18 years) who are not receiving aminoglycoside therapy.

Exclusion Criteria: (1) Current treatment with inhaled or ophthalmic aminoglycosides (2) Prior treatment with an aminoglycoside within the last 30 days

Trial design

166 participants in 3 patient groups

1

Description:

Hospitalized, untreated infants and children

Treatment:

Drug: aminoglycoside

2

Description:

Aminoglycoside treated infants and children without renal injury

Treatment:

Drug: aminoglycoside

3

Description:

Aminoglycoside treated infants with renal injury

Treatment:

Drug: aminoglycoside