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Identification of genes involved in congenital atrioventricular block and progressive Cardiac Conduction Disease.
Full description
Atrioventricular blocks are a heterogenous group of diseases involving children with congenital atrioventricular block (CAB) and more frequently elderly patients affected by progressive Cardiac Conduction Disease (PCCD).
The aim of the study is to uncover the genetic model, likely more complex than previously appreciated, and characterize the gene expression remodelling leading to high degree of conduction defect.
The recent technological developments in genomics coupled to the availability of large and highly characterized biobanks of patients have now set the stage:
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Inclusion and exclusion criteria
Congenital atrioventricular block inclusion criteria:
Congenital atrioventricular block exclusion criteria
Progressive Cardiac Conduction Disease inclusion criteria
Progressive Cardiac Conduction Disease exclusion criteria
2,600 participants in 4 patient groups
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Central trial contact
vincent PROBST, MD-PHD
Data sourced from clinicaltrials.gov
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