Identification of Genetic Markers and Predictors of Antidepressant-induced Suicidality in Youth Depression

Asan Medical Center

Status: Unknown

Conditions: Suicidal Ideation; Depression

Treatments: Drug: bupropion or lamotrigine

Study type: Observational

Funder types: Other

Identifiers

NCT02428439

S2015-0305-0003

Details and patient eligibility

About

The objective of this study is to identification of genetic markers and predictors of antidepressant-induced suicidality in youth depression. Participants who take the standardized pharmacotherapy (bupropion or lamotrigine) for depression will be observed for 8 weeks. They will do several scales and genetic tests at visit 1 (week 0), visit 3 (week 4) and visit 4 (week 8)

Enrollment: 80 estimated patients

Sex: All

Ages: 11 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged between 11 and 18 years
2. Met the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) diagnostic criteria for depressive episode or dysthymia
3. Intelligence quotient higher than 70 on the Korean Educational Developmental Institute's Wechsler Intelligence Scale for Children

Exclusion criteria

1. presence of intellectual disability
2. presence of hereditary disorder
3. past and/or current history of acquired brain injury, like cerebral palsy
4. presence of seizure, other neurological disorder or sensory impairments
5. past and/or current history of pervasive developmental disorder
6. past and/or current history of schizophrenia, bipolar disorder or psychosis
7. presence of severe learning disorder

Trial design

80 participants in 2 patient groups

Increased suicidality

Description:

Increase in suicidal ideation after taking the standardized pharmacotherapy (bupropion or lamotrigine) during 8 weeks.

Treatment:

Drug: bupropion or lamotrigine

Non-increased suicidality

Description:

Non-increase of suicidal ideation after taking the standardized pharmacotherapy (bupropion or lamotrigine) during 8 weeks.

Treatment:

Drug: bupropion or lamotrigine