Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy (GENECHOC)

Nantes University Hospital (NUH)

Status: Completed

Conditions: Cardiomyopathy

Treatments: Genetic: Identification of genetic polymorphisms

Study type: Observational

Funder types: Other

Identifiers

NCT02852018

PROG/10/77

Details and patient eligibility

About

The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.

Enrollment: 1,500 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients implanted for primary prevention, an implantable cardioverter defibrillator (ICD) single or double room, for severe cardiomyopathy (EF <35%)
• Patients with ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.- "Appropriate treatment" group: patients who had a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation
• Group "no event" patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive proper treatment during the follow up period of the study

Exclusion criteria

• Patients implanted with an ICD for primary prevention in the context of a family hereditary disease (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, ventricular tachycardia catecholergic right ventricular dysplasia ...).
• Patients with left ventricular function greater than 35%.
• Patients implanted with a defibrillator function resynchronization.
• Patients minors, adults under guardianship and protected persons are eligible under this project.

Trial design

1,500 participants in 2 patient groups

Appropriate treatment

Description:

Patients who have a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation

Treatment:

Genetic: Identification of genetic polymorphisms

No event

Description:

Patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive appropriate treatment during the follow up period of the study.

Treatment:

Genetic: Identification of genetic polymorphisms