Identification of Marker of Primary or Acquired Resistance to Anti Tumorous Treatment (MSN)

Gustave Roussy

Status: Unknown

Conditions: Melanoma; Small Cell Lung Cancer; Non Small Cell Lung Cancer

Treatments: Procedure: Healthy material sample; Procedure: Tumorous biopsy; Procedure: Blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT02105168

2007/1363 (Other Identifier)

2008-A00373-52

Details and patient eligibility

About

Lung Cancer and melanoma relapsed frequently whereas its very sensitive to treatment such as chemotherapy or radiotherapy. The purpose of this study is to have a better understanding of why those patients are relapsing using next generation sequencing to identify rare mutations and assessed their predictive value.

Enrollment: 2,200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Cytological or histological diagnosis of SCLC, NSCLC or melanoma
2. Patients age >/= 18 years old
3. Indication of treatment using platinum salts for lung cancer except for patient with NSCLC treated by surgery for whom platinum salts is not indicated
4. If a biopsy is proposed, lesion lust be easily accessible
5. Signed informed consent

Exclusion criteria

1. Patients unable to follow the protocol
2. Consent refusal

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

2,200 participants in 1 patient group

Experimental arm

Experimental group

Description:

Blood sample Tumorous biopsy Healthy material sample

Treatment:

Procedure: Healthy material sample

Procedure: Tumorous biopsy

Procedure: Blood sample