Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

The University of Texas System (UT)

Status: Enrolling

Conditions: Melanoma (Skin)

Study type: Observational

Funder types: Other

Identifiers

NCT06400550

STU 052018-031

Details and patient eligibility

About

The goal of this study is to observe metabolic features associated with human melanoma tumors.

Full description

This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received [U-13C]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision.
• Subjects of all races and ethnic origins over age 18.

Exclusion criteria

• Not a surgical candidate
• Poorly controlled diabetes

Trial design

400 participants in 2 patient groups

13C-glucose infusion

Description:

Tumor samples of patients who receive the optional 13C-glucose infusion will be studied using flux analysis and metabolomic profiling.

No 13C-glucose infusion

Description:

Tumor samples of patients who do not receive the optional 13C-glucose infusion will be studied using metabolomic profiling alone.