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Identification of Microbial Properties Predicting a Worsening Course of Fatty Liver Disease (FLM)

H

HaEmek Medical Center, Israel

Status

Terminated

Conditions

Patients With Fatty Liver Disease

Treatments

Other: fibroscan and stool sample

Study type

Observational

Funder types

Other

Identifiers

NCT03748511
179-17-EMC

Details and patient eligibility

About

This study investigates the relation between the gastrointestinal tract bacteria and the progression of fatty liver disease .

Full description

In the gastrointestinal (GI) tract live wide spectrum of bacteria, in this study we are trying to find if there is a relation between the GI tract bacteria and the development of non alcoholic fatty liver disease, the results of the this study may help us identify the stage of liver disease in noninvasive means and enables us to adopt methods to reduce morbodity.

Enrollment

62 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients with non alcoholic fatty liver disese.
  • patients who give approval to participate in the study

Exclusion criteria

  • liver failure
  • acute or chronic kidney failure
  • heart failure ( NYHA 3-4)
  • active cancer
  • fatty liver due to non alcoholic etiology.
  • patients who consume drugs from the estrogen/methotrexate family, or chloroquine.
  • history of hypothyrodism or cushing.
  • patients who used TPA in the last 6 months .
  • pathients with chronic liver disease like A1AT, hemochromatosis, wilson, toxic damage and autoimmunity .
  • special population like - children, pregnant women and patients who lack the ability to make judgment.
  • infectious liver disease - viral hepatitis or HIV.
  • inflammatory bowel disease.
  • patients who underwent surgery of the gastrointestinal trant.

Trial design

62 participants in 3 patient groups

fatty liver disease 0-1F
Description:
20 patients with uncomplicated liver disease, with fibrosis stage 0-1F.
Treatment:
Other: fibroscan and stool sample
fatty liver disease 2F
Description:
20 patients with liver disease, fibrosis stage 2F.
Treatment:
Other: fibroscan and stool sample
fatty liver disease 3-4F
Description:
20 patients with advanced liver disease, fibrosis stage 3-4F.
Treatment:
Other: fibroscan and stool sample

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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