Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.

Chongqing Medical University

Status: Active, not recruiting

Conditions: Obesity and Overweight

Treatments: Diagnostic Test: Measuring the microplastics

Study type: Observational

Funder types: Other

Identifiers

NCT06826586

2025-099-01

Details and patient eligibility

About

The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years old;
• BMI ≧30;
• proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test;
• complete clinical data and basic information;
• willing to participate in the study and sign the informed consent form.

Exclusion criteria

• Receive chemotherapy, radiotherapy, immunotherapy;
• have other history of digestive diseases;
• combined with malignant tumors;
• have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan;
• not willing to participate in this study.

Trial design

20 participants in 1 patient group

obesity group

Description:

BMI≧30

Treatment:

Diagnostic Test: Measuring the microplastics