Identification of Noninvasive Biomarkers for Neonates Undergoing Abdominal Surgery

Sichuan University

Status: Enrolling

Conditions: Neonate; Biomarkers

Treatments: Other: Biomarkers

Study type: Observational

Funder types: Other

Identifiers

NCT05181423

HX-2021657

Details and patient eligibility

About

To identify the potential serum and radiological biomarkers with regard to neonates undergoing abdominal surgery, and to further evaluate the prognostic value of these markers.

Full description

First, the investigators will collect serum biomarkers in neonate patients receiving abdominal surgery. Then the investigators will identify the characteristics and change of biomarkers expressed in neonate patients before and after abdominal surgery. The investigators will further evaluate the prognostic value of these markers for neonate patients receiving abdominal surgery.

Enrollment: 2,000 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age up to 18 years old
• With written informed consent

Exclusion criteria

• Clinical data missing
• Without written informed consent

Trial design

2,000 participants in 2 patient groups

Retrospective cohort

Description:

The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort.

Treatment:

Other: Biomarkers

Prospective cohort

Description:

The same inclusion/exclusion criteria were applied for the same center prospectively. It is a external validation cohort.

Treatment:

Other: Biomarkers